Endocrine Abstracts

Objective: The goal in this study was to evaluate serum parathormone (PTH) and 25-hydroxy-vitamin D (25OHD), calcium levels and bone mineral density (BMD) in patients with obesity and determine the relationship between biochemical bone parameters, body mass index (BMI) and trabecular/cortical BMD over a wide range of body weights.Methods: We examined 337 women (mean age 41.35 years old; BMI 45.47 kg/m2) who were classified into three categorie...

Objective: There has been no consensus on the medical management of diabetes in acromegaly patients. The primary approach is like the general population, and metformin is considered first-line therapy. Sodium-glucose cotransporter inhibitors (SGLT2is) are a novel antidiabetic class which has an improving effect on insulin resistance. There is no recommendation regarding their use for diabetic acromegaly patients despite their potential beneficial effects by inducing glucosuria...

Congenital adrenal hyperplasia (CAH) refers to an autosomal recessive condition due to 21 hydroxylase (21OHD) deficiency, is characterized by impaired biosynthesis of glucocorticoid and mineralocorticoid. The consequent increase in the ACTH leads to bilateral adrenocortical hyperplasia and hyperandrogenism. Nonclassic CAH (NCCAH) manifests with a less severe clinic that presents later in life with the sympthoms of excessive androgen production. Clinical features include premat...

Introduction: Acromegalic osteopathy is an emerging complication characterized by high risk for vertebral fractures (VFS), whereas bone mineral density (BMD) may not be useful to predict the risk. Recent studies have reported that increased advenced glycation end products (AGEs) are associated with bone fragility. We aimed to evaluate the relationship between AGEs and VFs in patients with acromegaly.Study design: Cross-sectionalPat...

The frequency of adrenal masses is increasing in parallel with the progress of the technology. Most of these masses, which are detected by chance, are not functional, and only a part of them are exposed to an excess of hormone. The most common dysfunction in masses with hormonal activity is hypercortisolism. However, the diagnosis of Cushing’s disease is based on more than one test. In this study, we intended to compare the values of screening tests to determine whether t...

Aim: The most common clinical presentation of primary hyperparathyroidism (PHPT) is asymptomatıc and it is diagnosed incidentally without developing complications.In our study, we aimed to examine the characteristics of participants with primary hyperparathyroidism and the relationship between bone mineral density (BMD) and hypercalciuria.Methods: Consecutive 191 normocalciuric (24-h urinary calcium<400 mg/day) patients with PHPT (51±13 yea...

Aim: Clinical presentation of primary hyperparathyroidism (PHPT) differs between populations. In this study, we aimed to examine bone mineral density (BMD) and bone metabolism parameters in newly diagnosed and untreated PHPT patients in a single endocrine center in İstanbul, Turkey.Methods: Consecutive 256 PHPT patients (50.7±14 years, F/M:205/51) and 89 healthy controls (38.8±10 years, F/M:67/22) were included in the study. Serum calcium...

Non adherence to medication schedules by patients with chronic illnesses has long been recognized as a problem. The aim of this study is to evaluate levothyroxine (L-T4) compliance, daily dosage and TSH levels under treatment in primary hypothyroid patients.We included 1636 primary hypothyroid patients over 1 year under L-T4 (F/M: 1469/167, 46±13 years of age) included from 11 tertiary health care ...